CYCLOPS statistics

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Citations per year

Number of citations per year for the bioinformatics software tool CYCLOPS

Tool usage distribution map

This map represents all the scientific publications referring to CYCLOPS per scientific context
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Associated diseases


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CYCLOPS specifications


Unique identifier OMICS_28845
Alternative name CYCLic Ordering by Periodic Structure
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages R, Julia
Computer skills Advanced
Stability Stable
tidyverse, CircStats, upsetR
Maintained Yes




No version available


  • person_outline John Hogenesch

Publications for CYCLic Ordering by Periodic Structure

CYCLOPS citations


Evidence for widespread dysregulation of circadian clock progression in human cancer

PMCID: 5797448
PMID: 29404219
DOI: 10.7717/peerj.4327

[…] Finally, we explored how dysregulation of clock progression might affect the circadian transcriptome. We obtained a set of 1,292 genes that were inferred by the CYCLOPS method to be rhythmic in a dataset from healthy human lung (). By applying WGCNA () to the same dataset, we grouped the 1,292 genes into five modules according to their co-expression (). Based […]


Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy

Int J Mol Sci
PMCID: 5666849
PMID: 29039812
DOI: 10.3390/ijms18102168

[…] d detoxification, molecular drug targets and their molecular clock control are necessary for optimally shaping the circadian drug delivery patterns to individual CTS in cancer patients. CYCLOPS i.e., cyclic ordering by periodic structure is very recently proposed algorithm by Anafi and coworkers []. To develop the algorithm, large human liver and lung biopsy as well as mouse tissue samples were co […]

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CYCLOPS institution(s)
Divisions of Human Genetics and Immunobiology, Center for Chronobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Divisions of Pediatric Otolaryngology and Pulmonary and Sleep Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, Cincinnati, OH, USA; Department of Medicine, Center for Sleep and Circadian Neurobiology, Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

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