Identifies information rich 2D scatter plots and extracts biological insights from them. CytoBinning is an application that permits to identify which specific regions of the scatter plot exhibits the most notable differences between two groups of donors and to allow subtle shifts in the immune phenotype to be highlighted. It also includes a list of important marker pairs and related important cell sub-regions.
Institute for Physical Science and Technology, University of Maryland, College Park, MD, USA; Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA; Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Bristol, UK; Inflammation and Immunotherapy Theme, National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital (National Health Service) Foundation Trust and University College London Institute of Ophthalmology, London, UK
CytoBinning funding source(s)
Supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, UK, AFOSR grant FA9550- 487 16-1-0052, the National Institutes of Health and National Eye Institute intramural research program.