Computational protocol: Defects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms

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Protocol publication

[…] A FAAH2 model structure was produced by threading the sequence of wild-type human FAAH2 onto a humanized rat FAAH1 template structure (PDB ID:2WAP) in Modeller 9.13 []. The p.Ala458Ser mutation was modeled in Coot [] with a rotamer selected to minimize steric clashes as determined by Molprobity []. Atoms within 3.5 Å and capable of forming hydrogen bonds with the hydroxyl group of p.Ser458 were identified in Coot. […]

Pipeline specifications

Software tools MODELLER, Coot, MolProbity
Application Protein structure analysis
Organisms Homo sapiens
Chemicals Amino Acids