Computational protocol: The importance of two metabolic syndrome diagnostic criteria and body fat distribution in predicting clinical severity and prognosis of acute myocardial infarction

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Protocol publication

[…] Baseline demographic and medical history parameters included gender, age, smoking, known family history of cardiovascular events (MI, stroke), previous MI, previous PCI and coronary artery bypass grafting (CABG). Data concerning long-term therapy before and after admission, including aspirin, β-blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), diuretics and statins, were also collected. According to current guidelines, all patients with acute STEMI and who had undergone PCI received dual antiaggregation therapy (aspirin and clopidogrel) and statin.Anthropometric baseline data included body adiposity index (BAI), BMI, conicity index (Cindex), visceral adiposity index (VAI), WC, WHR and WHtR [, , –]. Body mass index was calculated by dividing body weight in kilograms by the square of body height in meters (kg/m2) and classified as BMI < 25.0 (normal weight), BMI 25.0–29.9 kg/m2 (overweight) and BMI ≥ 30.0 kg/m2 (overall obesity). The WC was measured in the standing position at the midpoint between the lowest rib and the iliac crest. The cutoff values were ≥ 102/88 cm (central obesity) for males/females, respectively. The hip circumference was measured in the standing position between both major femoral trochanters. The WHR was calculated by dividing WC by hip circumference. The cutoff values were ≥ 0.90/0.85 (central obesity) for males/females, respectively. Cindex was calculated as follows: Cindex = WC/(0.109 × (weight/height)1.5) []. The cutoff values were 1.25 and 1.18 (central obesity) for males/females, respectively. The BAI was calculated using the equation suggested by Bergman et al.: BAI = (hip circumference/body height1.5) – 18 []. The cut-off values of overweight for males/females are 21/33% (20–39 years), 23/35% (40–59 years) and 25/38% (60–79 years), while cut-off values of central obesity are 26/39% (20–39 years), 29/41% (40–59 years) and 31/43% (60–79 years) []. The VAI was calculated by using the following formula: VAI (males) = (WC/39.68 + (1.88 × BMI)) × (TG/1.03) × (1.31/HDL) and VAI (females) = (WC/36.58 + (1.89 × BMI)) × (TG/0.81) × (1.52/HDL) []. The cut-off points for normal (normal weight) and increased VAI (central obesity) are 2.52 (age < 30 years), 2.23 (age ≥ 30 and < 42 years), 1.92 (age ≥ 42 and < 52 years), 1.93 (age ≥ 52 and < 66 years) and 2.00 (age ≥ 66 years) []. [...] Qualitative data were presented in absolute number and percentage. We used the χ2 test with Yates correction. Quantitative data were presented as median and corresponding interquartile range. Differences between the two groups were tested by Mann-Whitney U test. The χ2 test and univariate or multivariate logistic regression analysis were used to investigate the relationship between one dependent and one or several independent variables (after their adjustment) that may influence or predict the value of the dependent variable. The level of statistical significance was set at p < 0.05. Processing was done using the Statistica 6.0 for Windows software. […]

Pipeline specifications

Software tools CINdex, Statistica
Applications Miscellaneous, aCGH data analysis
Organisms Homo sapiens
Diseases Coronary Disease, Diabetes Mellitus, Diabetic Angiopathies, Heart Failure, Metabolic Diseases, Myocardial Infarction
Chemicals Cholesterol