Computational protocol: Applying a RapidPlan model trained on a technique and orientation to another: a feasibility and dosimetric evaluation

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Protocol publication

[…] Using the following DVH metrics, the dosimetric features were compared between the original vs. RP-VMAT, original vs. RP-IMRT plans and prone vs. supine setup orientations respectively: 1. homogeneity index of PGTV (HI_PGTV) and PTV (HI_PTV), defined as (D2 % − D98 %)/D50 %; 2. conformity index of PGTV (CI_PGTV) and PTV (CI_PTV), defined as V100 %/Vt arg et; 3. the relative volume exceeding 107 % of the prescribed dose to PGTV (V107 %, i.e. V54.14Gy); 4. Global maximum dose (Dmax) and near maximum dose in PGTV (D2 %) []; 5. The dose to 50 % of the femoral head volume and urinary bladder volume (D50 %_FH and D50 %_UB); 6. The mean dose to the femoral head and urinary bladder (Dmean_FH and Dmean_UB). 7. The total monitor units (MUs) of each plan.To assess the differences between the original plans and the knowledge based re-planning, paired samples t-test was conducted for normally distributed data (tested by Shapiro-Wilk method), otherwise Wilcoxon signed ranks test was performed using SPSS (version 21.0). To appraise the impact of supine and prone setup orientations on the dosimetric outcomes, independent sample t-test and Mann-Whitney U Test were carried out respectively for the data of normal and non-normal distributions. The equality of variances was examined by Levene's test. P < 0.05 was considered as statistically significant (2-tailed). Based on the tabular-formatted DVH data exported from Eclipse system, an in-house MATLAB code was programmed to calculate the mean DVHs of 30 patients that were either manually planned or knowledge-based re-planned. Plotting was performed using SigmaPlot software (Version 10.0, Systat, San Jose, CA). […]

Pipeline specifications

Software tools SPSS, SigmaPlot
Application Miscellaneous
Organisms Homo sapiens, Peru tomato mosaic virus