Computational protocol: Adherence to Chemoprophylaxis and Plasmodium falciparum Anti Circumsporozoite Seroconversion in a Prospective Cohort Study of Dutch Short Term Travelers

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Protocol publication

[…] Data analysis was performed with SPSS version 19.0.0.1 (2010, IBM, Somers, USA). Attack rates (ARs) and incidence rates (IRs) were based on positive anti-circumsporozoite antibody seroconversion indicative for exposure to P. falciparum. ARs were calculated by dividing the number of study subjects displaying seroconversion in the CSP-ELISA by the total number of participants at risk. IRs per 100 person-months were calculated by dividing the number of travelers with exposure to P. falciparum by our calculation of their exposure time. If a traveler was exposed to P. falciparum, we used half of their travel duration in endemic area as their exposure time; for travelers without exposure to P. falciparum, we used their total travel duration. Pearson chi-square tests of association were used to compare categorical variables between any two groups. Independent determinants for adherence to chemoprophylaxis and for use of DEET were identified by multiple logistic regression analysis and expressed as odds ratios with 95% confidence intervals. A p-value <0.05 was considered statistically significant. […]

Pipeline specifications

Software tools SPSS, TRAVeLer
Applications Miscellaneous, RNA structure analysis
Organisms Homo sapiens
Diseases Malaria
Chemicals DEET, Mefloquine