Computational protocol: Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells

Similar protocols

Protocol publication

[…] The mass spectrometry analysis was performed using an Orbitrap Velos as previously described. Orbitrap data were searched by Sequest under the software platform Proteome Discoverer 1.3 (Thermo, Rockford, IL, USA) against the human Swissprot (2012-02) protein sequence database (). […]

Pipeline specifications

Software tools Comet, Proteome Discoverer
Application MS-based untargeted proteomics
Organisms Homo sapiens
Diseases Melanoma, Neoplasms
Chemicals Tyrosine