DALI statistics

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Citations per year

Number of citations per year for the bioinformatics software tool DALI

Tool usage distribution map

This map represents all the scientific publications referring to DALI per scientific context
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Associated diseases

This word cloud represents DALI usage per disease context

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DALI specifications


Unique identifier OMICS_03645
Alternative names DaliLite, Dali server
Interface Web user interface
Restrictions to use None
Input data One or more protein structures in PDB format. The query structure can be specified as a PDB identifier plus chain identifier, or a PDB file uploaded by the user. All backbone atoms (N, CA, C, O) are required and the minimum chain length is 30 amino acids. If only the amino sequence is known, it can be mapped to the closest known structure by a sequence similarity search against PDB.
Output data PDB search, pairwise comparison and all-against-all comparison produce summaries of structural neighbours in a common output format and share interactive analysis tools.
Output format PDB,
Computer skills Basic
Stability Stable
Maintained Yes



  • person_outline Liisa Holm
  • person_outline Voytek Kasprzak

Publications for DALI


Dali server update.

2016 Nucleic Acids Res
PMCID: 4987910
PMID: 27131377
DOI: 10.1093/nar/gkw357

DALI citations


Structural basis for the recognition of complex type N glycans by Endoglycosidase S

Nat Commun
PMCID: 5951799
PMID: 29760474
DOI: 10.1038/s41467-018-04300-x

[…] Structure based sequence alignment analysis were performed using Chimera. Protein pocket volume was calculated using HOLLOW. Z-score values were produced by using DALI. Domain interface analysis was performed using PISA. Conserved and similar residues were labeled using BoxShade server (http://embnet.vital-it.ch/software/BOX_form.html). […]


Structure and mechanism of the two component α helical pore forming toxin YaxAB

Nat Commun
PMCID: 5935710
PMID: 29728606
DOI: 10.1038/s41467-018-04139-2

[…] α1-α6 (Fig. , helices with bold black outline). We found striking similarities between both head domains, with all structurally elucidated members from the wider ClyA family of α-PFTs, by performing DALI analysis (Supplementary Figure  and Supplementary Figure ). For alignments of the YaxA head domain, Z-scores ranged from 9.6 (soluble-monomeric ClyA, 5.5 Å RMSD; PDB code 1QOY) to 12.2 (NheA, 3.4 […]


Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin dockerin interaction

Sci Rep
PMCID: 5934362
PMID: 29725056
DOI: 10.1038/s41598-018-25171-8
call_split See protocol

[…] tion was found using a cohesin from R. flavefaciens strain 17 ScaB (unreleased) and an ensemble of 3 R. flavefaciens FD-1 dockerins (Doc1a from 5M2O, Doc1b from 5M2S and Doc3 from 5LXV) produced with Dali. The cohesin had a sequence identity of 33.0% and the dockerins between 22% (Doc3) and 34% (Doc1b). Two copies of the heterodimer RfCohScaB5-DocScaA complex were present in the asymmetric unit. T […]


Identification of a pyrophosphate dependent kinase and its donor selectivity determinants

Nat Commun
PMCID: 5931981
PMID: 29720581
DOI: 10.1038/s41467-018-04201-z

[…] tified based on structural similarity to a myo-inositol 3-kinase from the hyperthermophilic archaeon Thermococcus kodakarensis (MI3K_TK), which is an ATP-dependent member of the ribokinase family,. A Dali search with the substrate-complex structure of MI3K_TK (Protein Data Bank (PDB) ID 4XF7) showed that the structure is the most similar to the unliganded structure of TM0415 from the hyperthermoph […]


Structural and functional dissection of differentially expressed tomato WRKY transcripts in host defense response against the vascular wilt pathogen (Fusarium oxysporum f. sp. lycopersici)

PLoS One
PMCID: 5927432
PMID: 29709017
DOI: 10.1371/journal.pone.0193922

[…] expected values with mean H bond energy (-1.6 SD = 0.5) against the expected score values of -2.0 (SD = 0.8). The secondary structure assignment of the functional WRKY protein was analyzed using the DALI web server (http://ekhidna.biocenter.helsinki.fi/dali_server/start) []. The DALI results revealed that in the functional protein sequence 40.84% residues occupied or constituted the β strands. Ho […]


Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease

Sci Rep
PMCID: 5928061
PMID: 29713054
DOI: 10.1038/s41598-018-25237-7

[…] ins of human Angptl3 and Angptl4 share significant sequence and structural homology with other fibrinogen-like domains. Angptl3 can be superimposed on its closest structural homologues, identified by Dali server, Angiopoietins 1 and 2 with a rms deviation of 2.3 Å (192 equivalent Cα positions; 4JYO) or 2.4 Å (192 equivalent Cα positions; 1Z3S) respectively. Similarly angiopoietins 1 and 2 are the […]

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DALI institution(s)
Institute of Biotechnology, University of Helsinki, Finland; Department of Biosciences, University of Helsinki, Finland
DALI funding source(s)
Supported by Biocenter Finland.

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