DANN pipeline

DANN specifications


Unique identifier OMICS_06334
Alternative name Deleterious Annotation of genetic variants using Neural Networks
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Python
Parallelization CUDA
License MIT License
Computer skills Advanced
Stability Stable
Maintained Yes


  • Animals
    • Homo sapiens


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  • person_outline Xiaohui Xie <>

Publication for Deleterious Annotation of genetic variants using Neural Networks

DANN citation

PMCID: 5701300

[…] variants not known to be pathogenic were initially assigned medium priority. variants were promoted one priority level if they were predicted to be pathogenic by m-cap (m-cap score ≥ 0.25) or dann (dann score > 0.98) and/or lie in a gene flagged by the patient hpo terms. conversely, variants were demoted to low priority if they occur in genomic regions that are difficult to sequence […]

DANN institution(s)
Department of Computer Science, University of California, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, CA, USA
DANN funding source(s)
Supported by National Institute of Biomedical Imaging and Bioengineering, National Research Service Award (EB009418) from the University of California, Irvine, Center for Complex Biological Systems (NIH R01HG006870).

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