The patch clamp technique permits high-resolution recording of the ionic currents flowing through a cell's plasma membrane. In different configurations, this technique has allowed experimenters to record and manipulate the currents that flow either through single ion channels or those that flow across the whole plasma membrane.
Acquires and allows for the study of electrophysiological patch-clamp data. pCLAMP aims to control and save recording voltage-clamp, current-clamp and patch-clamp. It can be applied to basic ion channel research, cell pathway analysis, disease research or safety assessment. This tool comports graph plotting tools, event detection method and data conditioning such as filtering and baseline adjustment.
Offers an assortment of tools allowing users to perform data analysis, data acquisition and simulation of electrophysiological data. NeuroMatic provides an extensible toolkit that have to be run through the Igor platform software. It provides a wide range of functionalities including triggered stimulation, spike detection, simulations of stochastic synaptic transmission as well as voltage and current clamp.
Allows combined image and analogue signal acquisition and analysis. WinFluor is a program that enables users to simultaneously collect cell fluorescence image, patch clamp current and voltage signals. The software includes several features such as detection and analysis of event waveforms, display of excitation spectra, averaging of images or stimulus pulse generation.
Offers a platform intending to simplify the manipulation of oscillations, spikes, and neural signals. OpenElectrophy is a python package providing support features for the Neo software. The application can be run as both a graphic interface and a command-line application and proposes additional functions dedicated to storage, fast wavelet scalogram plotting or exploration of data coupled to a visualization tool.
Achieves hard real-time data acquisition and closed-loop control in biological experiments. RTXI is based on a Real-Time Operating System (RTOS) that modifies the operating system's native kernel architecture. It allows users to move developed and tested modules, algorithms, and entire closed-loop protocols from one computer to another without significant overhead. The tool is compatible with a wide range of experimentation hardware.
Enables the recording of all data from complex neuroscience experiments, involving both electrophysiology and multiple cameras. Vscope can be used to record image sequences from multiple cameras that view different areas of a preparation, or that image the same area in different spectral regions for ratiometric imaging using FRET-based dyes. This tool can be set up to automatically start trials at fixed intervals, which can be used for timed behavioral experiments and also for time-lapse imaging.