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Metagenomics can reveal the vast majority of microbes that have been missed by traditional cultivation-based methods. Due to its extremely wide range of application areas, fast metagenome sequencing simulation systems with high fidelity are in great demand to facilitate the development and comparison of metagenomics analysis tools.
(Jia et al., 2013) NeSSM: a Next-generation Sequencing Simulator for Metagenomics. PLoS One.