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database for nonsynonymous SNPs' functional predictions dbNSFP

Eases the process of filtering and prioritizing the presumably functional single nucleotide variants (SNVs) from a long list of SNVs identified in a typical whole exome sequencing (WES) study. dbNSFP can work as a local and self-sustaining database without need for internet connection. The database provides more than 82 800 000 non-synonymous SNVs (nsSNVs) and splice site SNVs (ssSNVs).

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2 user reviews

2 user reviews

ostrokach's avatar image ostrokach's country flag


Great dataset of SNP annotations.

Daniel Webber's avatar image

Daniel Webber

Works great with SnpEff for variant annotation.

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dbNSFP classification

  • Animals
    • Homo sapiens

dbNSFP specifications

Restrictions to use:
Data access:
File download
Community driven:
User data submission:
Not allowed

dbNSFP support



  • Xiaoming Liu <>


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Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

Funding source(s)

Supported by the US National Institutes of Health (5RC2HL102419 and U54HG003273).

Link to literature

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