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chevron_left Functional annotation Gene set enrichment analysis Topology enrichment analysis Gene Ontology annotation Microarray interconversion Over-representation analysis chevron_right
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DAVID specifications


Unique identifier OMICS_02220
Alternative names Database for Annotation, Visualization and Integrated Discovery, david bioinformatics resources
Interface Web user interface, Application programming interface
Restrictions to use None
Input data A list of gene identifiers.
Programming languages Java, MATLAB, Perl, Python
Computer skills Basic
Version 6.8
Stability Stable
Maintained Yes


  • person_outline Richard Lempicki
  • person_outline Xiaoli Jiao

Publications for Database for Annotation, Visualization and Integrated Discovery

DAVID citations


Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross linking

Nat Commun
PMCID: 5959879
PMID: 29777108
DOI: 10.1038/s41467-018-04355-w
call_split See protocol

[…] ical subtype. The GO analysis that was selected relies on the Expression Analysis Systematic Explorer (EASE) score (a p-value obtained through an adjusted Fisher’s exact test) and was performed using DAVID Bioinformatics Resources; the selected background was “Homo sapiens”. Each GO category was considered for further analyses only when fulfilled these three criteria: (1) is referred to GO biologi […]


A Five microRNA Signature for Survival Prognosis in Pancreatic Adenocarcinoma based on TCGA Data

Sci Rep
PMCID: 5955976
PMID: 29769534
DOI: 10.1038/s41598-018-22493-5
call_split See protocol

[…] n, miRDB, miRTarBase, and miRanda online analysis tools. To further enhance the reliability of the bioinformatic analysis, the overlapping target genes were identified using a Venn diagram. Using the DAVID and KOBAS online databases, the functional analysis of the GO annotation and KEGG signaling pathways were carried out. In the GO analysis, the categories included biological process (BP), cellul […]


Genomic alterations of ground glass nodular lung adenocarcinoma

Sci Rep
PMCID: 5955945
PMID: 29769567
DOI: 10.1038/s41598-018-25800-2

[…] DESeq/). Gene set enrichment tests were performed using the GAGE R tool. Clustering was performed by principal component analysis and hierarchical clustering. Gene ontology analyses were performed by DAVID (https://david.ncifcrf.gov/) and visualized by REVIGO (http://revigo.irb.hr/). The TopHat-fusion tool was used for the detection of fusion gene loci. […]


Comprehensive and integrative analysis identifies microRNA 106 as a novel non invasive biomarker for detection of gastric cancer

J Transl Med
PMCID: 5952699
PMID: 29764446
DOI: 10.1186/s12967-018-1510-y

[…] re screened by plug-in Molecular Complex Detection (MCODE) of Cytoscape. As for a further comment, KEGG pathway analysis was performed with the hub genes and genes involved in the selected modules by DAVID. […]


Molecular and clinical characterization of PTPN2 expression from RNA seq data of 996 brain gliomas

PMCID: 5953404
PMID: 29764444
DOI: 10.1186/s12974-018-1187-4
call_split See protocol

[…] med. Significantly related genes with PTPN2 expression were retrieved by using the Pearson correlation analysis. Gene ontology (GO) analyzed related gene sets and relevant biological functions on the DAVID website (http://david.ncifcrf.gov/) []. Cluster 3.0 (Human Genome Center, Institute of Medical Science, University of Tokyo, Japan) was used to plot heat maps of PTPN2 expression and correlated […]


Transcriptome analysis of alcohol treated microglia reveals downregulation of beta amyloid phagocytosis

PMCID: 5952855
PMID: 29759078
DOI: 10.1186/s12974-018-1184-7
call_split See protocol

[…] approach to minimize false discovery to 0.1% or less. This method does not take into consideration the magnitude of the difference in expression. Functional and pathway analysis were performed using DAVID [] and GO Consortium [, ] platforms. […]

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DAVID institution(s)
Laboratory of Immunopathogenesis and Bioinformatics, Frederick, MD, USA; Advanced Biomedical Computing Center, Frederick, MD, USA; Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA; Laboratory of Immuno-regulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
DAVID funding source(s)
Supported by the National Institute of Allergy and Infectious Diseases (NIAID), National institutes of Health (NIH), under Contract No. NOI-CO-56000.

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