|Application:||Gene expression microarray analysis|
|Number of samples:||79|
|Release date:||Jun 6 2012|
|Last update date:||Aug 12 2017|
|Diseases:||Encephalitis, California, Influenza, Human|
|Dataset link||Aged animals generate a robust immune response against swine origin 2009 pandemic H1N1 influenza A virus|
16 female rhesus macaques (Macaca Mulatta) 10-12 (Adult) and 20-24 years (Old/Aged) of age were used in these studies. Animals were infected with A/California/04/ 2009 H1N1 using a combinatory of intra-tracheal (4ml), intranasal (0.5 ml/nostril), and conjunctival (0.5 ml/eyelid) routes for a total dose of 7x106 TCID50 dose. Microarray analysis was performed on Bronchoalveolar lavage (BAL) samples collected on days 0, 4, 7, 10 and 14. Note: One of the Day 0 array did not pass QC metrics so for this animal the average of the other Day 0 samples from that group was utilized. At the end of the study animals were released back to the colony.
Richard Roy Green