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Citations per year

Number of citations per year for the bioinformatics software tool dbCLINE

Tool usage distribution map

This map represents all the scientific publications referring to dbCLINE per scientific context
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dbCLINE specifications


Unique identifier OMICS_08601
Name dbCLINE
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Anna Di Rienzo

Publication for dbCLINE

dbCLINE citations


Exploring the relationship between lifestyles, diets and genetic adaptations in humans

BMC Genet
PMCID: 4445807
PMID: 26018448
DOI: 10.1186/s12863-015-0212-1

[…] Viewing comparative analyses, data for other populations were retrieved from the database dbCLINE (http://genapps.uchicago.edu/software.html) from the Di Rienzo laboratory, which includes information from the International HaPMap Project Phase III (http://hapmap.ncbi.nlm.nih.gov/), the Hum […]


Genome Wide Analysis of Cold Adaptation in Indigenous Siberian Populations

PLoS One
PMCID: 4029955
PMID: 24847810
DOI: 10.1371/journal.pone.0098076

[…] variables in a panel of 61 worldwide populations, including three from Siberia (Maritime Chukchi, Naukan Yu'pik (Eskimos) and Yakut) . These data were obtained from http://genapps2.uchicago.edu:8081/dbcline/climate.tar.gz. Since we are interested in cold adaption selection signals we used the minimum winter temperature variable for comparison. We extracted the strongest signals with transformed r […]


On the stability of the Bayenv method in assessing human SNP environment associations

Hum Genomics
PMCID: 3896655
PMID: 24405978
DOI: 10.1186/1479-7364-8-1
call_split See protocol

[…] Allele frequency data on 623,318 SNPs from samples of 60 human populations from the freq_data file (61pops_climate_freqs.txt) on the dbCline website ( http://genapps2.uchicago.edu:8081/dbcline/main.jsp) were analyzed. The data set included samples from 52 HGDP populations plus Vasekela !Kung, Amhara, Naukan Yup’ik, Maritime Chukche […]


A general linear model based approach for inferring selection to climate

BMC Genet
PMCID: 3853933
PMID: 24053227
DOI: 10.1186/1471-2156-14-87

[…] 45 global populations using four climate variables, each quantified in both the summer and the winter seasons. We then compare our results with those of Hancock et al. (2011) [] available through the dbCLINE online database (http://genapps2.uchicago.edu:8081/dbcline/main.jsp), and identify a number of overlapping genomic regions as candidates for recent selection. […]


Human Expression QTLs Are Enriched in Signals of Environmental Adaptation

Genome Biol Evol
PMCID: 3787676
PMID: 23960253
DOI: 10.1093/gbe/evt124

[…] nk in BFs for a group of SNPs in the same ascertainment panel and within the same allele frequency bin. We obtained the data of transformed rank statistics for each SNP and environmental factors from dbCLINE (http://genapps2.uchicago.edu:8081/dbcline/main.jsp, last accessed January 20, 2012) or directly from the authors, Fumagalli et al. To summarize the evidence of association for each SNP with t […]


Loss and Gain of Function in SERPINB11: An Example of a Gene under Selection on Standing Variation, with Implications for Host Pathogen Interactions

PLoS One
PMCID: 3290568
PMID: 22393410
DOI: 10.1371/journal.pone.0032518

[…] iculture, and pastoralism), and main dietary component (cereals, fats-meat-and-milk, and roots-and-tubers) on SERPINB11 frequencies, we used a novel statistic, a Bayes factor, implemented through the dbCline database (http://genapps.uchicago.edu/labweb/index.html). This novel statistic measures the support for a model in which the allele frequencies of a SNP are dependent on an environmental varia […]

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dbCLINE institution(s)
Department of Human Genetics, University of Chicago, Chicago, IL, USA

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