dbCLINE statistics

info info

Citations per year


Popular tool citations

chevron_left Positive selection detection chevron_right

Tool usage distribution map

Tool usage distribution map
info info

Associated diseases

Associated diseases
Want to access the full stats & trends on this tool?


dbCLINE specifications


Unique identifier OMICS_08601
Name dbCLINE
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline Anna Di Rienzo

Publication for dbCLINE

dbCLINE citations


Exploring the relationship between lifestyles, diets and genetic adaptations in humans

BMC Genet
PMCID: 4445807
PMID: 26018448
DOI: 10.1186/s12863-015-0212-1

[…] the ld plots, considering a window of 200, 300 and 500 kb for plrp2, cyp3a5 and nat2 genes, respectively., viewing comparative analyses, data for other populations were retrieved from the database dbcline (http://genapps.uchicago.edu/software.html) from the di rienzo laboratory, which includes information from the international hapmap project phase iii (http://hapmap.ncbi.nlm.nih.gov/), […]


Genome Wide Analysis of Cold Adaptation in Indigenous Siberian Populations

PLoS One
PMCID: 4029955
PMID: 24847810
DOI: 10.1371/journal.pone.0098076

[…] variables in a panel of 61 worldwide populations, including three from siberia (maritime chukchi, naukan yu'pik (eskimos) and yakut) . these data were obtained from http://genapps2.uchicago.edu:8081/dbcline/climate.tar.gz. since we are interested in cold adaption selection signals we used the minimum winter temperature variable for comparison. we extracted the strongest signals with transformed […]


On the stability of the Bayenv method in assessing human SNP environment associations

Hum Genomics
PMCID: 3896655
PMID: 24405978
DOI: 10.1186/1479-7364-8-1

[…] indicated comparisons are averaged and presented. in table  , letters a, b, c, and d also correspond to parts e, f, g, and h, respectively. hancock1 refers to the original climate file posted on the dbcline website and published in hancock et al. []; hancock2 refers to file climate.2 posted on dbcline website in autumn 2012 that uses the appropriate mcmc burn-in (see ‘methods’ section); blair1-5 […]


A general linear model based approach for inferring selection to climate

BMC Genet
PMCID: 3853933
PMID: 24053227
DOI: 10.1186/1471-2156-14-87

[…] global populations using four climate variables, each quantified in both the summer and the winter seasons. we then compare our results with those of hancock et al. (2011) [] available through the dbcline online database (http://genapps2.uchicago.edu:8081/dbcline/main.jsp), and identify a number of overlapping genomic regions as candidates for recent selection., the method we propose […]


Human Expression QTLs Are Enriched in Signals of Environmental Adaptation

Genome Biol Evol
PMCID: 3787676
PMID: 23960253
DOI: 10.1093/gbe/evt124

[…] in bfs for a group of snps in the same ascertainment panel and within the same allele frequency bin. we obtained the data of transformed rank statistics for each snp and environmental factors from dbcline (http://genapps2.uchicago.edu:8081/dbcline/main.jsp, last accessed january 20, 2012) or directly from the authors, fumagalli et al. to summarize the evidence of association for each snp […]

Want to access the full list of citations?
dbCLINE institution(s)
Department of Human Genetics, University of Chicago, Chicago, IL, USA

dbCLINE reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review dbCLINE