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DDI-CPI specifications


Unique identifier OMICS_04108
Alternative name Drug-Drug Interaction via Chemical-Protein Interactome
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained No


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Publication for Drug-Drug Interaction via Chemical-Protein Interactome

DDI-CPI citations


A Computational Approach Using Bioinformatics to Screening Drug Targets for Leishmania infantum Species

PMCID: 5896251
PMID: 29785196
DOI: 10.1155/2018/6813467

[…] (CPI) refers to the information of interaction of a panel of chemicals across target proteins, in terms of binding strength and conformation to each chemical-protein pocket pair []. Both DRAR-CPI and DDI-CPI servers are employed for computational drug repositioning by the CPI server [, ]. The molecular structure of strychnobiflavone was submitted to the DRAR-CPI and DDI-CPI servers, and parameters […]


Protective effects of Araloside C against myocardial ischaemia/reperfusion injury: potential involvement of heat shock protein 90

J Cell Mol Med
PMCID: 5571541
PMID: 28225183
DOI: 10.1111/jcmm.13107

[…] The interaction information of Araloside C was predicted using the DDI‐CPI tool, a web‐based server that can predict drug–drug interactions via the chemical–protein interactome. The molecular file of Araloside C was downloaded and pre‐treated following the web instru […]


Identification of a Potential Target of Capsaicin by Computational Target Fishing

PMCID: 4681817
PMID: 26770256
DOI: 10.1155/2015/983951
call_split See protocol

[…] the interaction information of a panel of chemicals across a panel of target proteins in terms of binding strength and binding conformation for each chemical-protein pocket pair []. Both DRAR-CPI and DDI-CPI are the servers for computational drug repositioning via the CPI [, ].The molecular file of capsaicin was downloaded and pretreated following the web instructions as described previously [, ]. […]


A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver

Drug Des Devel Ther
PMCID: 4529259
PMID: 26347199
DOI: 10.2147/DDDT.S85426

[…] First, we computationally predicted the molecular targets of UA using our web-based DDI-CPI tool. There were 611 proteins that possibly interacted with UA (), including those involved in MAPK signaling pathway (FGFR2, TRAF2, FGFR1, HRAS, GRB2, MAPKAPK3, MAPKAPK2, AKT1, CDC42, TNFRSF1 […]


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DDI-CPI institution(s)
Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China; University of Arkansas at Little Rock/University of Arkansas for Medical Sciences, Little Rock, AR, USA; Healthcare Analytics Research Group, IBM TJ Watson Research Center, Yorktown Heights, NY, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Heath, Boston, MA, USA; Department of Bioengineering, University of California at Berkeley, Berkeley, CA, USA; School of Pharmacy, Fudan University, Shanghai, China

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