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DDI specifications


Unique identifier OMICS_05550
Name DDI
Alternative name Drug-Drug Interactions
Software type Package/Module
Interface Command line interface
Restrictions to use Academic or non-commercial use
Input data Sentences
Output data DDI
Operating system Unix/Linux, Mac OS, Windows
Programming languages Java
Computer skills Advanced
Stability Stable
Maintained Yes




No version available

Publication for Drug-Drug Interactions

DDI citations


Predicting and understanding comprehensive drug drug interactions via semi nonnegative matrix factorization

BMC Syst Biol
PMCID: 5907306
PMID: 29671393
DOI: 10.1186/s12918-018-0532-7

[…] -prescription. Moreover, the important structural relationship hidden among DDIs still remains unknown.To address the abovementioned issues, we have designed a novel approach DDINMF for comprehensive DDI prediction in different scenarios. Treating the set of DDI as a network, it provides a unified framework for predicting conventional binary DDIs as well as comprehensive DDIs. Experiments on the d […]


Information needs for making clinical recommendations about potential drug drug interactions: a synthesis of literature review and interviews

BMC Med Inform Decis Mak
PMCID: 5322613
PMID: 28228132
DOI: 10.1186/s12911-017-0419-3

[…] of workflows, rather than demonstration of work in context, interview contents and analysis may suffer from problems of recall and de-contextualization. Additional interviews involving observation of DDI evidence review in situ might provide additional insights [, ]. Although our analytic processes, including coding by multiple reviewers and consensus revisions to codebooks, should increase the ge […]


Using Nonexperts for Annotating Pharmacokinetic Drug Drug Interaction Mentions in Product Labeling: A Feasibility Study

PMCID: 4844909
PMID: 27066806
DOI: 10.2196/resprot.5028

[…] eminating drug information. However, the structure in these documents is only in the form of high-level sections such as Description, Indications and Usage, Contraindications, and Warnings. Specific PDDI details are given in plain text, tables, and figures within the Drug Interactions section or other locations throughout the label. Although future efforts may lead to more structured and therefore […]


Drug Drug Interaction Extraction via Convolutional Neural Networks

PMCID: 4752975
PMID: 26941831
DOI: 10.1155/2016/6918381

[…] The CNN-based DDI extraction system is developed and evaluated on the DDI corpus of the 2013 DDIExtraction challenge [], which is composed of 730 DrugBank documents and 175 MEDLINE abstracts about DDIs. The corpus […]


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DDI institution(s)
Department of Medical Informatics, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands; Informatics Institute, University of Amsterdam, Amsterdam, Netherlands; Complexity Institute, Nanyang Technological University, Singapore, Singapore; ITMO University, St. Petersburg, Russia
DDI funding source(s)
Supported by Russian Scientific Foundation, proposal #14-21-0037.

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