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DDRprot specifications


Unique identifier OMICS_12813
Name DDRprot
Alternative name DNA Damage Response proteins
Restrictions to use None
Database management system MySQL
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes


  • person_outline Ana Rojas

Publication for DNA Damage Response proteins

DDRprot citations


Targeting Polo like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor

PMCID: 5722562
PMID: 29228610
DOI: 10.18632/oncotarget.21932

[…] uction of DNA damage further, we analyzed the expression of proteins associated with DNA damage repair and apoptosis. BT16 and MAF-A737 cells were treated with BI 6727 for 72 hours, and expression of DNA damage response proteins and apoptotic proteins was evaluated by western blot. PLK1 inhibition strongly decreased DNA repair genes, such as 53BP1, Ku80, and RAD51, and induced expression of p53, f […]


The Role of DCT in HPV16 Infection of HaCaTs

PLoS One
PMCID: 5240977
PMID: 28095444
DOI: 10.1371/journal.pone.0170158

[…] ells, we wanted to check the degree of DNA damage in these cells. H2A.X is a histone 2A variant and it becomes phosphorylated at Ser139 when there is DNA-damage and this phosphorylated state recruits DNA-damage response proteins to the site of damage []. To detect DNA damage in DCT knockdown cells, we checked the cellular levels of this damage marker via pH2A.X (Ser139) antibody. pH2A.X protein wa […]


Systematic Characterization of Cell Cycle Phase dependent Protein Dynamics and Pathway Activities by High content Microscopy assisted Cell Cycle Phenotyping

PMCID: 4411490
PMID: 25458086
DOI: 10.1016/j.gpb.2014.10.004

[…] eline to analyze the cell cycle phase-dependent localization of any two proteins and their interaction within the nucleus. We successfully applied this pipeline to analyze the dynamic localization of DNA damage response proteins (53BP1, Rad51, γH2AX, etc.) throughout the cell cycle . […]


The human DEK oncogene regulates DNA damage response signaling and repair

Nucleic Acids Res
PMCID: 3177200
PMID: 21653549
DOI: 10.1093/nar/gkr454

[…] Whole cell lysates were harvested with RIPA buffer containing phosphatase inhibitors and analyzed as described previously (). For detection of DNA damage response proteins, cells were lysed in 50 mM Tris–HCl, pH 7.4, 250 mM NaCl and 5 mM EGTA, supplemented with protease and phosphatase inhibitors (BD Biosciences, San Jose, CA, USA). Primary […]


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DDRprot institution(s)
Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville, Sevilla, Spain; Cell Movements in Development and Disease Lab, Instituto de Neurociencias (CSIC-UMH), Alicante, Spain
DDRprot funding source(s)
Supported by the European Commission grant [FP7-REGPOT-2012-2013-1; the Spanish Ministry of Science and Innovation grant [PS09/02111].

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