Computational protocol: CHAT gene polymorphism rs3810950 is associated with the risk of Alzheimer’s disease in the Czech population

Similar protocols

Protocol publication

[…] The N-terminal domains (1st-126th residue) of the M isoform of ChAT non-mutant protein and mutant A120T of the same isoform were prepared using ab initio modelling Robetta server (http://robetta.bakerlab.org/) and homology modelling software MODELLER []. Search for hydrogen bond network was done via VMD [], Schrodinger Maestro software (Schrodinger, L. Biologics Suite 2017–1) and PyMOL (The PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC.) as well as the visualization device. […]

Pipeline specifications

Software tools Robetta, MODELLER, VMD, PyMOL
Application Protein structure analysis
Organisms Merluccius merluccius, Homo sapiens
Diseases Alzheimer Disease
Chemicals Amino Acids, Choline