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A free online database of image and phenotype data for embryonic lethal knockout mice. The data sheds new light on genes that are critical for embryo development and survival. High-resolution 3D image analysis and tissue histology is used to identify abnormalities in both embryos and placentas from embryonic lethal lines. The data is searchable by gene or phenotype, all full-resolution images are available and phenotypes are annotated on the relevant images. Phenotype penetrance data is available for each line. The database also includes gene expression profiles for embryos from knockout lines.

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DMDD classification

  • Animals
    • Mus musculus

DMDD specifications

License:
CC Attribution-NonCommercial-ShareAlike
Version:
2015.11
Data access:
Web user interface

DMDD support

Maintainer

Credits

Publications

  • (Wilson et al., 2016) Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines. Nucleic acids research.
    PMID: 26519470
  • (Mohun et al., 2013) Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice. Disease models & mechanisms.
    PMID: 23519034

Institution(s)

The Francis Crick Institute Mill Hill Laboratory, London, UK

Funding source(s)

This project is funded by the Wellcome Trust with support from the Francis Crick Institute.

Link to literature

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