DeepTox specifications

Information


Unique identifier OMICS_27077
Name DeepTox
Software type Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Sepp Hochreiter <>

Publication for DeepTox

DeepTox in publications

 (3)
PMCID: 5938574
PMID: 29618526
DOI: 10.1098/rsif.2017.0387

[…] of jointly modelling far more targets than the merck challenge [,], with ramsundar et al. [] showing that the benefits of multi-task networks had not yet saturated even with 259 targets. although deeptox [], a deep learning approach, won another competition, the toxicology in the 21st century (tox21) data challenge, it did not dominate alternative methods as thoroughly as in other domains. […]

PMCID: 5826228
PMID: 29515993
DOI: 10.3389/fchem.2018.00030

[…] the best performance in the test set was 0.84 and 0.79, respectively (chen et al., ). the tox21 project also includes nuclear receptors assays which involve more diverse compounds (hsieh et al., ). deeptox, the winner of the “tox21 data challenge,” used deep neural network and obtained an excellent performance against other machine learning methods such as svm (mayr et al., )., previous studies […]

PMCID: 5851934
PMID: 29552648
DOI: 10.1016/j.synbio.2017.11.002

[…] include a scoring system based on assessing the toxicity of intermediate metabolites of a pathway in a host cell , . for example, a database like tox21 and a deep learning based algorithm (deeptox) have been applied to identify potentially toxic effects of chemical compounds. the selection of pathway ranking method(s) depends on the design goal. for example, in order to design […]


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DeepTox institution(s)
Institute of Bioinformatics, Johannes Kepler University Linz, Linz, Austria; RISC Software GmbH, Johannes Kepler University Linz, Hagenberg, Austria
DeepTox funding source(s)
Supported by ChemBioBridge and MrSymBioMath.

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