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DEG specifications


Unique identifier OMICS_08725
Name DEG
Alternative name Database of Essential Genes
Restrictions to use None
Version 11.0
Maintained No

Publications for Database of Essential Genes

DEG citations


The Druggable Pocketome of Corynebacterium diphtheriae: A New Approach for in silico Putative Druggable Targets

Front Genet
PMCID: 5816920
PMID: 29487617
DOI: 10.3389/fgene.2018.00044

[…] an approach based on subtractive genomics was implemented and applied to the GD targets that were essential to bacteria (). Briefly, the set of target proteins of C. diphtheriae was submitted to the Database of Essential Genes (DEG, which contains experimentally validated essential genes from bacteria, archaea and eukaryotes) for homology analyses (). Again, we used BLASTp with E-value cut-off of […]


A Comprehensive Overview of Online Resources to Identify and Predict Bacterial Essential Genes

Front Microbiol
PMCID: 5711816
PMID: 29230204
DOI: 10.3389/fmicb.2017.02331

[…] n of the development of secondary databases about essential genes. In the following part, we list some available web resources and servers related to essential genes and discuss them in detail.DEG (a database of essential genes) is a comprehensive platform for essential genes. This database was constructed in 2004 and has been updated constantly. The newly released DEG 10 contains a considerable n […]


Comparative analysis of the Burkholderia cenocepacia K56 2 essential genome reveals cell envelope functions that are uniquely required for survival in species of the genus Burkholderia

Microb Genom
PMCID: 5729917
PMID: 29208119
DOI: 10.1099/mgen.0.000140

[…] Bcc, Burkholderia cepacia complex; CF, cystic fibrosis; COG, cluster of orthologous group; DEG, database of essential genes; HDTM, high-density transposon mutagenesis; ORF, open reading frame; LPS, lipopolysaccharide; PrhaB, rhamnose-inducible promoter; Tn-seq, transposon sequencing; UID, unique […]


Complete Genome Sequence of Vibrio campbellii LMB 29 Isolated from Red Drum with Four Native Megaplasmids

Front Microbiol
PMCID: 5660062
PMID: 29109705
DOI: 10.3389/fmicb.2017.02035

[…] re performed using Mauve with progressive Mauve option (Darling et al., ). IslandViewer 4 was applied to predict genomic islands in V. campbellii LMB29 with default settings (Bertelli et al., ). DEG (Database of Essential Genes) database (version 14.7) was used to assess gene essentiality of ORFs predicted in LMB29 with BLAST search (Luo et al., ). […]


An integrative in silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae

PLoS One
PMCID: 5648181
PMID: 29049350
DOI: 10.1371/journal.pone.0186401

[…] was next followed for the selection of conserved targets, which were essential to the bacteria []. Concisely, the set of proteins derived from the core-modelome of C. diphtheriae was subjected to the Database of Essential Genes (DEG) for homology analyses. The DEG encompasses experimentally validated data of currently available essential genomic elements like protein-coding genes and non-coding RN […]


Genetic Interaction Network as an Important Determinant of Gene Order in Genome Evolution

Mol Biol Evol
PMCID: 5850728
PMID: 29029158
DOI: 10.1093/molbev/msx264

[…] ned from the SGD. Three-dimensional chromatin colocalization data were retrieved from . Genome-wide gene expression noise data were downloaded from . A list of essential genes was downloaded from the Database of Essential Genes (DEG, version 10.6) (). Semantic similarity of Gene Ontology (GO) terms was calculated using the R package GOSemSim (version 1.22.0) (). […]


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DEG institution(s)
Department of Physics, Tianjin University, Tianjin, China

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