Contains the results of the manual annotation of every protease gene in the genomes of human, chimpanzee, mouse, and rat, along with relationships between protease alterations and hereditary diseases. The annotations about each individual protease can be retrieved by browsing catalytic classes and families or by searching specific terms. This Degradome database also provides detailed information about genetic diseases of proteolysis, a growing field of great importance for multiple users. Finally, the user can find additional information about protease structures, protease inhibitors, ancillary domains of proteases and differences between mammalian degradomes.
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain
Degradome database funding source(s)
European Union [CancerDegradome-FP6 and MicroEnviMet-FP7]; Ministerio de Economía y Competitividad-Spain, Principado de Asturias and Fundación Botín (supported by Banco Santander through its Santander Universities Global Division)