DeltaGREM specifications


Unique identifier OMICS_26621
Name DeltaGREM
Software type Application/Script
Interface Command line interface
Restrictions to use Academic or non-commercial use
Input data A multiple sequence alignment.
Input format PDB
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Registration required Yes
Maintained Yes


No version available


  • person_outline Ugo Bastolla

Publication for DeltaGREM

DeltaGREM citation


Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus

Genome Biol Evol
PMCID: 5433387
PMID: 28460010
DOI: 10.1093/gbe/evx075

[…] tions (Pearson’s chi-squared test: df = 1, χ2 = 36.9, P < 10−8; ). Furthermore, the impact on 3D’s folding free energy (ΔΔG) of every possible non-synonymous mutation was evaluated using PoPMuSiC and DeltaGREM (described in Materials and Methods). Both methods indicate that, on average, U → C mutations have a much stronger destabilizing effect on the protein than C → U mutations (Welch’s two-taile […]

DeltaGREM institution(s)
Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain
DeltaGREM funding source(s)
Supported by the Spanish Ministry of Economy and Competitiveness through grant BFU2012-40020.

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