DEMETER statistics

info info

Citations per year

Number of citations per year for the bioinformatics software tool DEMETER

Tool usage distribution map

This map represents all the scientific publications referring to DEMETER per scientific context
info info

Associated diseases


Popular tool citations

chevron_left High-throughput RNAi screening chevron_right
Want to access the full stats & trends on this tool?

DEMETER specifications


Unique identifier OMICS_29150
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input format CSV
Operating system Unix/Linux
Programming languages C++, R, Shell (Bash)
Computer skills Advanced
Stability Stable
Maintained Yes




No version available



  • person_outline David Root
  • person_outline Aviad Tsherniak
  • person_outline James McFarland
  • person_outline Zandra Ho
  • person_outline Guillaume Kugener

Publication for DEMETER

DEMETER citations


Functional genomics identifies specific vulnerabilities in PTEN deficient breast cancer

PMCID: 5863852
PMID: 29566768
DOI: 10.1186/s13058-018-0949-3

[…] to identify broad-spectrum PTEN-SSL genes by extracting gene-level sensitivity scores reported for each dataset (Fig. ). Although each screen was performed using different scoring approaches (zGARP, DEMETER, and z scores), increasingly negative scores indicate greater inhibition of cell growth in all cases. We determined the PTEN status of 75 breast cancer cell lines based on previously published […]


Patient derived xenografts undergo murine specific tumor evolution

Nat Genet
PMCID: 5659952
PMID: 28991255
DOI: 10.1038/ng.3967

[…] s normalized to RPKM values for each gene. Gene essentiality profiles for each cell line were derived from genome-wide RNAi screens across 503 cell lines (n = 446 with arm-level CNA calls), using the DEMETER algorithm to isolate gene knockdown effects from off-target effects. Drug sensitivity measurements were taken from the Cancer Therapeutics Response Portal (CTRP v2) dataset (downloaded from ht […]

Want to access the full list of citations?
DEMETER institution(s)
Broad Institute of MIT and Harvard, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Boston Children’s Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
DEMETER funding source(s)
Supported by NIH U01 CA176058, NIH ICBP grant U54 CA112962, and The Carlos Slim Foundation in Mexico through the Slim Initiative for Genomic Medicine.

DEMETER reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review DEMETER