DEMETER statistics

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Associated diseases

Associated diseases

DEMETER specifications


Unique identifier OMICS_29150
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input format CSV
Operating system Unix/Linux
Programming languages C++, R, Shell (Bash)
Computer skills Advanced
Stability Stable
Maintained Yes



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  • person_outline David Root <>
  • person_outline Aviad Tsherniak <>
  • person_outline James McFarland <>
  • person_outline Zandra Ho <>
  • person_outline Guillaume Kugener <>

Publication for DEMETER

DEMETER in publications

PMCID: 5863852
PMID: 29566768
DOI: 10.1186/s13058-018-0949-3

[…] for each study. per-gene zgarp scores were downloaded from the breast functional genomics study website ( [] and these are available in additional file : table s11. demeter z scores for the cancer dependency map dataset (achilles v2.20.2 gene solutions) were downloaded from the project achilles website ( […]

PMCID: 5659952
PMID: 28991255
DOI: 10.1038/ng.3967

[…] normalized to rpkm values for each gene. gene essentiality profiles for each cell line were derived from genome-wide rnai screens across 503 cell lines (n = 446 with arm-level cna calls), using the demeter algorithm to isolate gene knockdown effects from off-target effects. drug sensitivity measurements were taken from the cancer therapeutics response portal (ctrp v2) dataset (downloaded […]

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DEMETER institution(s)
Broad Institute of MIT and Harvard, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Boston Children’s Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA
DEMETER funding source(s)
Supported by NIH U01 CA176058, NIH ICBP grant U54 CA112962, and The Carlos Slim Foundation in Mexico through the Slim Initiative for Genomic Medicine.

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