bookmark DephosSite Obsolete Predicts the substrate dephosphorylation sites of three specific phosphatases, namely, PTP1B, SHP-1, and SHP-2. DephosSite provides two predictors, MGPS-DEPHOS and CKSAAP-DEPHOS. MGPS-DEPHOS is modified from Group-based Prediction System algorithm with an interpretable capability. CKSAAP-DEPHOS is built through the combination of support vector machine and the composition of k-spaced amino acid pairs encoding scheme. Benchmarking experiments using jackknife cross validation and 30-times 5-fold cross validation tests show that both methods outperformed the previous developed kNN algorithm.