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Coverage/Depth analysis software tools | High-throughput sequencing data analysis

The theoretical or expected coverage is the average number of times that each nucleotide is expected to be sequenced given a certain number of reads of a given length and the assumption that reads are randomly distributed across an idealized genome(Lander et al., 2001). Actual empirical per-base coverage represents the exact number of times that a base in the reference is covered by a high-quality aligned read from a given sequencing experiment. Redundancy of coverage is also called the depth or the depth of coverage. Source text : Sims et al., 2014.

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