An open access database of families of repetitive DNA elements, in which each family is represented by a multiple sequence alignment and a profile hidden Markov model (HMM). Dfam families include retrotransposons, DNA transposons, interspersed repeats of unknown origin, and a number of non- transposable element (TE) entries used to annotate satellites or to avoid annotating noncoding RNA genes as TEs.
Institute for Systems Biology, Seattle, WA, USA; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; HHMI Janelia Research Campus, Ashburn, VA, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA; Genetic Information Research Institute, Los Altos, CA, USA; University of Montana, Missoula, MT, USA
Dfam funding source(s)
This work was supported by the Howard Hughes Medical Institute Janelia Research Campus and the National Institutes of Health [P41LM006252–1, RO1 HG002939]. The new Dfam database and web server was partially funded by a grant from the University of Montana University Grant Program.