DFprot specifications


Unique identifier OMICS_26599
Name DFprot
Interface Web user interface
Restrictions to use None
Computer skills Basic
Source code URL http://chaconlab.org/multiscale-simulations/dfprot/df-down?task=callelement&format=raw&item_id=15&element=f85c494b-2b32-4109-b8c1-083cca2b7db6&method=download&args%5B0%5D=44802b9c8a6bc4e4c1322a4970fd5569
Maintained Yes


  • person_outline Pablo Chacon

Publication for DFprot

DFprot citations


Drug Like Protein–Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology

Mol Inform
PMCID: 4160817
PMID: 25254076
DOI: 10.1002/minf.201400040

[…] ucture-based in silico screening was performed by targeting the VEGF-binding zone of the extracellular domain D2 of VEGFR-1. As flexibility is known to be important at protein–protein interfaces, the DFprot server was used to investigate the possible plasticity of the D2 domain of VEGFR-1.[] Analysis of the X-ray structure (with the probe mapping algorithm ProtoMol implemented in the screening pac […]


Prediction of protein motions from amino acid sequence and its application to protein protein interaction

BMC Struct Biol
PMCID: 3245509
PMID: 20626880
DOI: 10.1186/1472-6807-10-20

[…] ormations of the same protein.Recently, web-based tools for predicting internal motion have been developed. For example, FlexOracle [] and HingeProt [] predict hinge regions in proteins. Furthermore, DFprot [] predicts main-chain deformability, which corresponds fundamentally to the internal motions described above.However, all these tools, along with NMA, offer only limited practical use because […]

DFprot institution(s)
Centro de Investigaciones Biologicas, CSIC, Madrid, Spain; Department of Molecular Biology, The Scripps Research Institute La Jolla, CA, USA
DFprot funding source(s)
Supported by funds from BFU2004-01282 and Fundacion BBVA and NIH 1-R01-GM071872-01.

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