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Protocols

DGIdb specifications

Information


Unique identifier OMICS_04002
Name DGIdb
Alternative name Drug–Gene Interaction database
Restrictions to use None
Database management system PostgreSQL
Community driven No
Data access Browse
User data submission Not allowed
Version 3.0
Maintained Yes

Maintainers


  • person_outline Obi L. Griffith
  • person_outline Alex Wagner

Publications for Drug–Gene Interaction database

DGIdb citations

 (23)
library_books

VAReporter: variant reporter for cancer research of massive parallel sequencing

2018
BMC Genomics
PMCID: 5954270
PMID: 29764369
DOI: 10.1186/s12864-018-4468-5

[…] riety of biomedical databases, including dbSNP [], 1000 Genomes [], COSMIC, the Cancer Gene Census [], dbNSFP [], Clinvar [], OMIM [], RefSeq [], UniProt [], Pfam [], GO [], KEGG [], DrugBank [], the DGIdb [] and the Human Gene Mutation Database [] (HGMD), were compiled as local annotation databases to facilitate the interpretation of biological effects introduced by genetic alterations. A high-pe […]

library_books

Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets

2018
Sci Rep
PMCID: 5821758
PMID: 29467471
DOI: 10.1038/s41598-018-20721-6

[…] t with (from the ConsensusPathDB) were checked with the HGNC Multi-symbol Checker. All unique gene names (including HGNC and non-HGNC converted names) were listed and checked for drug interactions in DGIdb v2.22 (Interaction.tsv file). Genes with at least one drug in the database were assigned a score of 2.Mouse phenotype. A list of all the genes that had atherosclerosis phenotypes in mice was obt […]

library_books

DGIdb 3.0: a redesign and expansion of the drug–gene interaction database

2017
Nucleic Acids Res
PMCID: 5888642
PMID: 29156001
DOI: 10.1093/nar/gkx1143

[…] n of the content of the database through the addition of new sources and the updating of existing sources. Six new sources have been added, which brings the total number of sources represented by the DGIdb to 30. Three of these new sources provide drug–gene interactions from prominent expert-curated databases of clinically actionable variants similar to the CIViC and Clearity Foundation sources, a […]

call_split

Differential prioritization of therapies to subtypes of triple negative breast cancer using a systems medicine method

2017
Oncotarget
PMCID: 5696233
PMID: 29190967
DOI: 10.18632/oncotarget.21669
call_split See protocol

[…] se of experimentally validated drug-protein associations, also referred to as drug-target signatures, was curated from the following publicly accessible databases: (1) Drug Gene Interaction Database (DGIdb) [] (accessed April 20, 2016), and (2) Comparative Toxicogenomics Database (CTD) [] (accessed March 4, 2016). Within the CTD, only interactions with a “binder” designation were used to establish […]

library_books

Resources for Interpreting Variants in Precision Genomic Oncology Applications

2017
PMCID: 5610688
PMID: 28975082
DOI: 10.3389/fonc.2017.00214

[…] ommunity editors, in various stages of interpreting the clinical significance of cancer variants using standards and guidelines developed by community experts (, ).The Drug Gene Interaction Database (DGIdb) is an open source and open access platform for gene and drug annotation for known interaction and potential druggability. Users can cross-reference genes of interest and drugs against up to 15 […]

library_books

Cell Type Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome

2017
Neuron
PMCID: 5548955
PMID: 28772121
DOI: 10.1016/j.neuron.2017.07.013

[…] using the GO_molecular_function 2015 library. Number of drugs interacting with Genes differentially regulated in the Fmr1-/y CA1-TRAP were quantified using the Drug Gene Interaction database (http://dgidb.genome.wustl.edu/) (). […]

Citations

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DGIdb institution(s)
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
DGIdb funding source(s)
Supported by the National Human Genome Research Institute [R00HG007940]; the National Cancer Institute [K22CA188163]; the NCI [T32CA113275, F32CA206247]; the National Cancer Institute [T32CA113275] and National Institute of General Medical Sciences [5R25GM103757]; the National Cancer Institute [U01CA209936].

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