DIANA-mirExTra statistics

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Associated diseases

Associated diseases

DIANA-mirExTra specifications


Unique identifier OMICS_05978
Name DIANA-mirExTra
Interface Web user interface
Restrictions to use None
Input data A miRNA/RNA-Seq read count data sets.
Programming languages Javascript, PHP
Database management system PostgreSQL
Computer skills Basic
Version 2.0
Stability Stable
Maintained Yes


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus


  • person_outline Artemis G. Hatzigeorgiou <>
  • person_outline Ioannis S. Vlachos <>

Publications for DIANA-mirExTra

DIANA-mirExTra in publications

PMCID: 5576712
PMID: 28854209
DOI: 10.1371/journal.pone.0181242

[…] in silico analysis of differentially expressed (de) genes to identify potential upstream mirnas., to identify candidate mirnas, we performed in silico analyses using starbase [], targetscan [], and diana-mirextra []. each of these methods identifies regulatory interaction networks among multiple classes of rna. candidate mirnas that were identified by any of these methods were considered […]

PMCID: 4924816
PMID: 27351379
DOI: 10.1371/journal.pone.0158043

[…] the geo (ncbi geo; gse60436). the regulatory relationships between the identified mirnas and the differentially expressed genes in active fvm were analyzed using in silico functional analyses with diana-mirextra. these data showed that the expressions of the identified mirnas were negatively correlated with their predicted mrna targets ( and tables), suggesting that these mirnas were actively […]

PMCID: 4705652
PMID: 26578605
DOI: 10.1093/nar/gkv1221

[…] polya sites. it provides graphs of mirna enrichment associated with up- or down-regulated transcripts and summary tables of selected mrna targets and their functional annotations by gene ontology. diana-mirextra () is a web server that identifies primarily the mirnas inducing gene deregulation by targeting six nucleotide-long motifs (hexamers) that are overrepresented in the 3′ utr sequences […]

PMCID: 4519289
PMID: 26222740
DOI: 10.1371/journal.pone.0130938

[…] 6.0 can be accessed from the following address: /dianatools/index.php?r=tarbase/index. next, we performed an analysis of expression data for microrna function using the diana0mirextra tool. diana-mirextra is an algorithm that can identify microrna effects to the expression levels of protein-coding transcripts, based on the frequency of six nucleotide long motifs (hexamers) in the 3'utr […]

PMCID: 4669786
PMID: 25695604
DOI: 10.1038/cddis.2015.10

[…] of the downregulated transcripts. this consensus motif was complementary to the positions 2–8 from the 5′ end of mir-663, the crucial seed region required for target recognition (). moreover, diana-mirextra hexamer analysis confirmed that the direct targets of mir-663 were enriched in the 91 downregulated genes ()., to identify downstream genes of aicd/mir-663 signaling […]

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DIANA-mirExTra institution(s)
DIANA-Lab, Department of Electrical & Computer Engineering, University of Thessaly, Volos, Greece; Hellenic Pasteur Institute, Athens, Greece; Laboratory for Experimental Surgery and Surgical Research ‘N.S. Christeas’, Medical School of Athens, University of Athens, Athens, Greece; ‘Athena’ Research and Innovation Center, Athens, Greece; Miroculus, San Francisco, CA, USA
DIANA-mirExTra funding source(s)
Supported by the project “NGS-infect” from the Greek General Secretary of Research and Technology and by a Fondation Sante grant.

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