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A method for predicting Dicer cleavage sites. LBSizeCleav offers a feature space mapping by introducing the length of a loop/bulge structure into the algorithm. The binary pattern of LBSizeCleav is an extension of PHDCleav. To evaluate this method, 810 empirically validated sequences of human pre-miRNAs were used and fivefold cross-validation were performed. In both 5p and 3p arms of pre-miRNAs, LBSizeCleav showed greater prediction accuracy than PHDCleav did. This result suggests that the length of loop/bulge structures is useful for prediction of Dicer cleavage sites.
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