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n the transcriptome analysis domain, differential co-expression analysis (DCEA) is emerging as a unique complement to traditional differential expression analysis. Rather than calculating expression level changes of individual genes, DCEA investigates differences in gene interconnection by calculating the expression correlation changes of gene pairs between two conditions.
(Yang et al., 2013) DCGL v2.0: an R package for unveiling differential regulation from differential co-expression. PLoS One.