Unlock your biological data


Differential methylation site identification software tools | DNA methylation microarray data analysis

After correct preprocessing of the data (i.e. filtering out problematic probes and normalizing the data), differential methylation analysis can be performed. Generally, the first approach consists in a single-probe analysis. Statistical tests (such as the t-test or Mann–Whitney test) are used, and when the P-values obtained are below a given threshold (e.g. <0.05), the sites are considered as differentially methylated and referred as differentially methylated positions (DMPs). In this way, several researchers have identified numerous DMPs although the absolute difference in methylation of the CpG sites between two groups of samples was small (i.e. below 5% of methylation difference).

Source text:
(Dedeurwaerder et al., 2014) A comprehensive overview of Infinium HumanMethylation450 data processing. Brief Bioinform.

1 - 16 of 16 results
filter_list Filters
build Technology
laptop Operating System
desktop_windows Interface
important_devices Computer Skill
copyright Restriction to use
memory Programming Language
healing Disease
import_contacts Journal
account_balance Funding
1 - 16 of 16 results
0 - 0 of 0 results
1 - 2 of 2 results
filter_list Filters
assignment_ind Position
public Country