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Differential network data analysis software tools | Protein interaction

Analogous to differential expression analysis, differential network analysis involves pairwise subtraction of interactions that have been mapped in different experimental conditions (Ideker and Krogan, 2012). The subtractive process filters out ubiquitous interactions (so‑called ‘housekeeping’ interactions) that are common to all static conditions of interest. By selectively extracting interactions that are relevant to the studied condition or phenotype, this reduces the typical complexity of static networks. Source text: Mitra et al., 2013.

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