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Differential network analysis software tools | Biological pathway

Analogous to differential expression analysis, differential network analysis involves pairwise subtraction of interactions that have been mapped in different experimental conditions (Ideker and Krogan, 2012). The subtractive process filters out…
xMWAS
Web
Desktop

xMWAS

Improves the understanding of complex molecular interactions and disease…

Improves the understanding of complex molecular interactions and disease mechanisms for integrative analysis, differential network analysis, and community detection. xMWAS recognizes and displays…

DC3NET
Desktop

DC3NET Differential C3NET

Performs differential network analysis to infer disease specific gene networks.…

Performs differential network analysis to infer disease specific gene networks. dc3net is a package that infers direct physical interactions of differential gene networks from gene expression…

Diffany
Desktop

Diffany Differential network analysis tool

A generic, ontology-driven framework to infer, visualise and analyse an…

A generic, ontology-driven framework to infer, visualise and analyse an arbitrary set of condition-specific responses against one reference network. To this end, we have implemented novel…

DINA
Web

DINA DIfferential Network Analysis

Quantifies the variability in the co-regulation probability of genes across…

Quantifies the variability in the co-regulation probability of genes across tissues or conditions. DINA is an approach based on detecting differences in the number of edges among genes in a pathway…

DyNet
Desktop

DyNet

A Cytoscape plug-in that visualizes differences among multiple networks. DyNet…

A Cytoscape plug-in that visualizes differences among multiple networks. DyNet can be used for analysing how networks change over time or across multiple conditions (dynamic networks). DyNet utilizes…

PPICompare
Desktop

PPICompare

Detects significantly rewired interactions between samples of two groups of…

Detects significantly rewired interactions between samples of two groups of condition-specific protein-protein interaction networks (PPINs). PPICompare is a differential PPIN tool that statistically…

G T A T C G C T A
INDEED
Algorithm

INDEED Integrated DiffErential Expression and Differential network analysis

Builds a sparse differential network based on partial correlation for better…

Builds a sparse differential network based on partial correlation for better visualization, and integrates differential expression (DE) and differential network (DN) analyses for biomarker discovery.…

Joint density…
Desktop
DINGO
Desktop

DINGO Differential Network Analysis in Genomics

A pathway-based differential network analysis in genomics model for estimating…

A pathway-based differential network analysis in genomics model for estimating group-specific networks as well as making inference on the differential networks. DINGO jointly estimates the…

KDDN
Desktop

KDDN Knowledge-fused Differential Dependency Network

A Cytoscape app to learn biological network topology and its changes using…

A Cytoscape app to learn biological network topology and its changes using profiling data and domain knowledge. It takes input data and runs KDDN algorithm to construct the dependency network. When…

DDN
Desktop

DDN Differential Dependency Network

A caBIG (cancer Biomedical Informatics Grid) analytical tool for detecting and…

A caBIG (cancer Biomedical Informatics Grid) analytical tool for detecting and visualizing statistically significant topological changes in transcriptional networks representing two biological…

DiffNet
Desktop

DiffNet

Provides an implementation of statistically significant differential…

Provides an implementation of statistically significant differential sub-network analysis for paired biological networks. DiffNet performs differential network analysis for paired biological networks…

DNA
Desktop

DNA Differential Network Analysis

A package for conducting a differential analysis of networks constructed from…

A package for conducting a differential analysis of networks constructed from microarray data under two experimental settings. Examining changes in network structure can provide valuable information…

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