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DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling. Differentially methylated regions (DMRs) have important implications for development, aging and diseases. Therefore, genome-wide mapping of DMRs across various temporal and spatial methylomes is important in revealing the impact of epigenetic modifications on heritable phenotypic variation.
(Zhang et al., 2011) QDMR: a quantitative method for identification of differentially methylated regions by entropy. Nucleic Acids Res.