Provides a comprehensive, curated, multidimensional database for developmental phenotypes, cell-specific gene functions, differentiation trajectories and a multiscale model of lineage differentiation in the C. elegans embryo. Digital development stores data from recent systematic studies of cell lineage differentiation in the C. elegans embryo containing ∼200 conserved genes, 1400 perturbed cell lineages and 600 000 digitized single cells. Users can conveniently browse, search and download four categories of phenotypic and functional information from an intuitive web interface. This information includes lineage differentiation phenotypes, cell-specific gene functions, differentiation landscapes and fate choices, and a multiscale model of lineage differentiation. Digital Development provides a comprehensive, curated, multidimensional database for developmental biology. The scale, resolution and richness of biological information presented here facilitate exploration of gene-specific and systems-level mechanisms of lineage differentiation in Metazoans.

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Digital development classification

  • Animals
    • Caenorhabditis elegans

Digital development specifications

Restrictions to use:
None

Publications

  • (Santella et al., 2015) Digital development: a database of cell lineage differentiation in C. elegans with lineage phenotypes, cell-specific gene functions and a multiscale model. Nucleic acids research.
    DOI: 10.1093/nar/gkv1119

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Maintainer

Credits

Institution(s)

Sloan Kettering Institute, New York, NY 10065, USA; Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

Funding source(s)

NIH [GM097576 and HD075602]; MSK Cancer Center Support/Core [P30 CA008748]; China's Recruitment Program for Young Professionals (Thousand Youth Talents Plan) and National Natural Science Foundation of China [31571535 and NIH OD010943]

Link to literature

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