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DIOPT-DIST specifications


Unique identifier OMICS_15274
Alternative name DIOPT Diseases and Traits
Interface Web user interface
Restrictions to use None
Input data A list of genes from model organisms, a list of orthologs, a disease term, disease category or OMIM IDs.
Output data The DIOPT scores, hyper-links to detailed information (the protein alignment, the original tool scores).
Programming languages Perl
Database management system MySQL
Computer skills Basic
Stability Stable
Maintained Yes


  • Invertebrates
    • Caenorhabditis elegans
    • Drosophila melanogaster
  • Plants and Fungi
    • Saccharomyces cerevisiae
  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
  • Vertebrates
    • Danio rerio



  • person_outline Stephanie Mohr

Publication for DIOPT Diseases and Traits

DIOPT-DIST citations


Cross phenotype association tests uncover genes mediating nutrient response in Drosophila

BMC Genomics
PMCID: 5095962
PMID: 27809764
DOI: 10.1186/s12864-016-3137-9

[…] polymorphic positions with minor allele frequency ≥5 % (1,932,643 total). For analysis of human disease orthologs, we subjected the set of FlyBase genes with human homologs [] to a homolog search via DIOPT-DIST [, ] to find best-match human-Drosophila homologs, and then filtered for human genes with entries in the Online Mendelian Inheritance in Man database []. All DGRP polymorphisms with minor a […]


Genome Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster

PLoS Genet
PMCID: 4709145
PMID: 26751788
DOI: 10.1371/journal.pgen.1005616

[…] We combined candidate genes from GWA analyses of all phenotypes and searched for orthologs in humans using DIOPT-DIST []. Enrichment of GWA candidates for genes with human orthologs associated with height [] was determined with a hypergeometric test (function phyper() in R). We determined Drosophila orthol […]


Insights into ALS pathomechanisms: from flies to humans

PMCID: 4826116
PMID: 26594942
DOI: 10.1080/19336934.2015.1114694

[…] developed tool for ortholog mapping, and we found that out of the 85 modifiers 77 have a human homolog. The human genes were subjected to analysis with the DIST tool on DIOPT (http://www.flyrnai.org/diopt-dist) to determine whether any of them is known to be associated with any neurological disorder in humans. Information retrieved from the Online Mendelian Inheritance in Man data sets and Genome […]


Identification of Drosophila Mutants Affecting Defense to an Entomopathogenic Fungus

Sci Rep
PMCID: 4511952
PMID: 26202798
DOI: 10.1038/srep12350

[…] We used the DRSC platform (http://www.flyrnai.org) to identify human orthologs and disease traits, and analyze alignments and scores. The DIOPT-DIST search tool in DRSC includes information from the NCBI OMIM database and genome-wide association studies. A low score (≤2) was excluded unless it was the only match score. […]


Network Analyses Reveal Novel Aspects of ALS Pathogenesis

PLoS Genet
PMCID: 4380362
PMID: 25826266
DOI: 10.1371/journal.pgen.1005107

[…] is orthologue is supported by only one algorithm.To search whether any of the identified modifiers are known to be associated with a disease of the nervous system, we used a tool based on DIOPT named DIOPT-DIST (http://www.flyrnai.org/diopt-dist). The DIOPT-DIST website links Drosophila genes to high-confidence orthologues of disease genes extracting information from the Online Mendelian Inheritan […]


A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis

PMCID: 4232771
PMID: 25361581
DOI: 10.1242/bio.201410066

[…] action within genetic interaction, the information from these databases was curated manually. The network map was constructed using Cytoscape V2.8.3. Ortholog prediction was performed using DIOPT and DIOPT-DIST tools (http://www.flyrnai.org/diopt). Score of 1 on a scale of 10 was set as threshold to consider a gene as an ortholog. DIOPT combines information from different prediction tools to sugge […]


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DIOPT-DIST institution(s)
Drosophila RNAi Screening Center, Department of Genetics, Harvard Medical School, Boston, MA, USA; Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA; Math Department and Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA
DIOPT-DIST funding source(s)
This work was supported by NIH R01 GM067761, in part by the Dana Farber/Harvard Cancer Center, by NIDDK 5K08DK78361 and Harvard Catalyst.

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