DiscoTope protocols

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DiscoTope specifications

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Unique identifier OMICS_04199
Name DiscoTope
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for DiscoTope

DiscoTope in pipelines

 (2)
2016
PMCID: 4742598
PMID: 26866023
DOI: 10.7774/cevr.2016.5.1.41

[…] the dinnna online software was used for disulfide bound prediction (http://clavius.bc.edu/~clotelab/dianna/)., web-based algorithm servers, bcepred (http://www.imtech.res.in/raghava/bcepred/) and discotope (http://www.cbs.dtu.dk/services/discotop/), were used for prediction of continuous and discontinue b-cell epitopes, respectively. mhc super type a1 by netctl 1.2 server […]

2013
PMCID: 3722629
PMID: 23901192
DOI: 10.4103/0971-6866.112885

[…] analyzed to predict continuous and discontinuous b cell epitopes using the bcepred program (http://www.imtech.res.in/raghava/bcepred)[] and the disco tope 1.2 server (http://www.cbs.dtu.dk/services/discotope/), respectively.[], among different haplotypes of major histocompatibility molecules (mhc) in mice, those of the balb/c mice harboring h2d were selected. these alleles contain i-ad and i-ed […]


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DiscoTope in publications

 (49)
PMCID: 5857104
PMID: 29548281
DOI: 10.1186/s12879-018-3007-y

[…] linear b cell epitope by all profiles (4/5, 80%) except antigenicity (see fig. ). second, (b) using the crystal structure of tmkmt (pdb entry: “1g3u”) and discontinuous b cell epitope software discotope, we derived 22 amino acids ( a:g57, a:e148, a:s150, a:r151, a:g152, a:r153, a:a154, a:q155, a:r156, a:d157, a:p158, a:g159, a:a160, a:a161, a:r162, a:a163, a:n164, a:e166, a:r167, a:d168, […]

PMCID: 5778136
PMID: 29403456
DOI: 10.3389/fmicb.2018.00001

[…] and amino acid substitutions were mapped on the predicted structure using chimera v1.10.2 ()., next, we predicted b-cell conformational epitopes in the capsid protein in the structural models by discotope2.0 (), bepro (), epces (), and epsvr (). we used these tools with cut-offs of -3.7 (discotope2.0), 1.3 (bepro), and 70 (epces, epsvr). we accepted sites as b-cell conformational epitopes […]

PMCID: 5763123
PMID: 29445754
DOI: 10.1155/2017/2680160

[…] methods to predict conformational b-cell epitopes (). the first to be introduced was cep [], which relied almost entirely on predicting patches of solvent-exposed residues. it was followed by discotope [], which, in addition to solvent accessibility, considered amino acid statistics and spatial information to predict conformational b-cell epitopes. an independent evaluation of these two […]

PMCID: 5915707
PMID: 29713601
DOI: 10.15171/bi.2018.06

[…] predicted based on the artificial neural network algorithm (windows size 14, threshold 0.51). the conformational epitopes were selected based on the high-score outcomes of seppa v2.0, ellipro, and discotope v2.0 (threshold: -3.7) online servers. , the protein sequence of local eg14-3-3 was aligned with five ncbi’s complete sequences of other reported eg14-3-3 isolate (genbank accessions: […]

PMCID: 5723339
PMID: 29259596
DOI: 10.3389/fmicb.2017.02399

[…] yerseke 2006a: ef126963, den haag 2006b: ef126965, osaka 2007: ab434770, apeldoorn 2007: gu270580, new orleans 2009: gu445325, sydney 2012: jx459908) were predicted using the following four tools: discotope 2.0 (kringelum et al., ), bepro (sweredoski and baldi, ), epces (liang et al., ), and epsvr (liang et al., ). cut-off values of epitopes were set at −3.7 (discotope 2.0), 1.3 (bepro), […]


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DiscoTope institution(s)
Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark

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