DiseaseConnect statistics

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Citations per year

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Popular tool citations

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Tool usage distribution map

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Associated diseases

Associated diseases

DiseaseConnect specifications

Information


Unique identifier OMICS_04646
Name DiseaseConnect
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Maintainer


  • person_outline Chun-Chi Liu <>

Publication for DiseaseConnect

DiseaseConnect in publications

 (6)
PMCID: 5701033
PMID: 29170401
DOI: 10.1038/s41598-017-16270-z

[…] pid, of which 223 pathways were selected from the nci-nature curated database, 254 pathways were collected from the biocarta database, and 838 pathways were obtained from the reactome database., diseaseconnect (http://disease-connect.org/) is a public web-server for the analysis and visualization of comprehensive knowledge regarding common molecular mechanism-based disease-disease […]

PMCID: 5384674
PMID: 28388656
DOI: 10.1371/journal.pone.0174964

[…] organized in a hierarchical tree[,]. based on the 23 mesh headings, which were extrapolated manually by trained experts, we searched the coremine pubmed search engine system[], the omim[], and the diseaseconnect[] databases to extract disease-gene relationships. moreover, we manually examined and verified disease-gene co-occurrence in the literature contained in the pubmed database, in order […]

PMCID: 5215297
PMID: 28054643
DOI: 10.1038/srep40137

[…] between the modules and curated ais-related genes. the curated ais-related genes were extracted from three phenotype-genotype associations, including the coremine literature database, omim and diseaseconnect. the human interactome data were filtered from the string 9.1 ppi database. we used a widely used community detection method (i.e., bgll) to identify topological modules […]

PMCID: 4726080
PMID: 26777674
DOI: 10.1038/srep19633

[…] proteins (genes) found for each hpa categories. we then compared the number of publications between categories to evaluate the possibility of publication bias (student t-test)., the diseaseconnect database, which associates genes with diseases, was used to link cofactor-interacting proteins to diseases. for the present analysis, data from omim (which included 3,644 genes […]

PMCID: 4599653
PMID: 26450611
DOI: 10.1186/s13062-015-0088-z

[…] of differential expression values of protein interaction modules between different diseases as the disease similarity measure, and found out 138 significant similarities between diseases []. diseaseconnect, a web server, also utilized differentially expressed genes to explore disease relationships []. these studies adopted a common understanding that diseases are highly correlated […]


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DiseaseConnect institution(s)
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan; Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan; Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA
DiseaseConnect funding source(s)
The National Institutes of Health (NIH) [NHLBI MAPGEN U01HL108634 and NIGMS R01GM105431] and the National Science Foundation [0747475]; the National Science Council grant [NSC101–2627-B-005–002] and the Ministry of Education, Taiwan, R.O.C. under the ATU plan; the National Institutes of Health (NIH) [NHLBI MAPGEN U01HL108630]

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