A web server for analysis and visualization of a comprehensive knowledge on mechanism-based disease connectivity. DiseaseConnect integrates comprehensive omics and literature data, including a large amount of gene expression data, genome-wide association studies catalog, and text-mined knowledge, to discover disease-disease connectivity via common molecular mechanisms. Moreover, the clinical comorbidity data and a comprehensive compilation of known drug-disease relationships are additionally utilized for advancing the understanding of the disease landscape and for facilitating the mechanism-based development of new drug treatments.
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan; Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan; Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA
DiseaseConnect funding source(s)
The National Institutes of Health (NIH) [NHLBI MAPGEN U01HL108634 and NIGMS R01GM105431] and the National Science Foundation ; the National Science Council grant [NSC101–2627-B-005–002] and the Ministry of Education, Taiwan, R.O.C. under the ATU plan; the National Institutes of Health (NIH) [NHLBI MAPGEN U01HL108630]