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DISOPRED specifications


Unique identifier OMICS_03618
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for DISOPRED

DISOPRED citations


Characterization of a novel organic solute transporter homologue from Clonorchis sinensis

PLoS Negl Trop Dis
PMCID: 5942847
PMID: 29702646
DOI: 10.1371/journal.pntd.0006459

[…] was split into two domains, comprising an N-terminal ordered (or folded) domain (CsOST-N; Met1 to Arg354; 354 aa) and C-terminal disordered (or unfolded) domain (CsOST-C; Arg355–Leu480; 126 aa) using DISOPRED3 []. To build a molecular model, a short fragment (Met1–Leu23) was removed, and the remainder of CsOST-N and CsOST-C were used for accurate model prediction. Initial three-dimensional (3D) mo […]


Deciphering the dark proteome of Chikungunya virus

Sci Rep
PMCID: 5895634
PMID: 29643398
DOI: 10.1038/s41598-018-23969-0

[…] Prot ID: Q8JUX6 and Q8JUX5]. Previously, for disorder analysis, several specialized predictors have been developed, for example, PONDR® pool [PONDR® FIT, PONDR® VLS2, PONDR® VLXT], as well as IUPred, DisoPred, DisEMBL, GlobPlot, SPRITZ, and much more. To evaluate the precision of disorder predictors, several aforementioned tools were compared within the frames of the Critical Assessment of Protein […]


Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1

Sci Rep
PMCID: 5832771
PMID: 29497085
DOI: 10.1038/s41598-018-21952-3

[…] positive charges of the peptides, and the fact that the peptide sequences are part of the C-terminal domain of AtEIN2, which is predicted to be mainly disordered (60% disordered regions according to DISOPRED).As no experimental structure of the ETR1 GAF domain has been reported so far, we used our in-house software package TopModel to build a structural model based on available templates (Supplem […]


Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation

PMCID: 5862610
PMID: 29568389
DOI: 10.18632/oncotarget.24459

[…] (from NCBI) was performed with the aim to identify the existing crystal structures with high identity and similarity. Additionally, we performed disorder tendency and protein binding analysis through DISOPRED, which highlight the probability estimation of each residue in the sequence. All details of the molecular modeling of the NKX2.5 model (N-term + HD) and GATA4 model were given in the material […]


Discovery of Cryoprotective Activity in Human Genome Derived Intrinsically Disordered Proteins

Int J Mol Sci
PMCID: 5855623
PMID: 29385704
DOI: 10.3390/ijms19020401

[…] ly achieved through bioinformatics, which is coping with a rapidly increasing number of genome sequences. Examples of prediction tools in this category include DisEMBL [], GlobPlot [], PONDR VSL1 [], DISOPRED [], DISpro [], and VSL2 []. We also developed different IDP predictors, DICHOT [,], and a series of web applications named POODLE [,,]. In this study, we designed our experiment based mainly […]


Pi Pi contacts are an overlooked protein feature relevant to phase separation

PMCID: 5847340
PMID: 29424691
DOI: 10.7554/eLife.31486.045

[…] Per residue disorder predictions were obtained using Disopred3.16 () (standard command line and Refseq database) and IUPRED-Long (; ) against the phase separation test and training sets, the PDB test set, the human Disprot set, and a random selection of […]


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DISOPRED institution(s)
Bioinformatics Group, Department of Computer Science, University College London, Gower Street, London, UK

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