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DISpro specifications


Unique identifier OMICS_26469
Name DISpro
Software type Application/Script
Interface Command line interface
Restrictions to use Academic or non-commercial use
Operating system Unix/Linux
Computer skills Advanced
Version 1.0
Stability Stable
Maintained Yes




No version available


  • person_outline Pierre Baldi

Publication for DISpro

DISpro citations


Discovery of Cryoprotective Activity in Human Genome Derived Intrinsically Disordered Proteins

Int J Mol Sci
PMCID: 5855623
PMID: 29385704
DOI: 10.3390/ijms19020401

[…] hrough bioinformatics, which is coping with a rapidly increasing number of genome sequences. Examples of prediction tools in this category include DisEMBL [], GlobPlot [], PONDR VSL1 [], DISOPRED [], DISpro [], and VSL2 []. We also developed different IDP predictors, DICHOT [,], and a series of web applications named POODLE [,,]. In this study, we designed our experiment based mainly on the POODLE […]


NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

Sci Rep
PMCID: 5511132
PMID: 28710492
DOI: 10.1038/s41598-017-05325-w
call_split See protocol

[…] e secondary structure of our NEK1 crystallographic structure to validate our analysis. We also performed disordered regions analysis using nine different predictors: FoldIndex, GlobPlot, PONDR VL-XT, DISpro, IUPred, DisEMBL Hot-loops, DisEMBL Remark-465, DisEMBL Loops/coils and VSL2B. From this, a consensus of predicted disordered regions was generated with a consensus score ranging from 0 to 9, w […]


Equity Theory Ratios as Causal Schemas

Front Psychol
PMCID: 4990720
PMID: 27594846
DOI: 10.3389/fpsyg.2016.01257

[…] ceived to have taken place, as exemplified in the balanced proportionality condition.The results for disproportionality are a little less straight forward. There is definitely a sense of receiving in dispro portionality and it gets more intense as the disproportionality gets stronger. This is consistent with expectations based on equity ratios (Hypothesis 2A). Moreover, it is definitely perceived […]


Factors Determining Staphylococcus aureus Susceptibility to Photoantimicrobial Chemotherapy: RsbU Activity, Staphyloxanthin Level, and Membrane Fluidity

Front Microbiol
PMCID: 4949386
PMID: 27486456
DOI: 10.3389/fmicb.2016.01141

[…] pred/ (accessed 30.04.2015)], SSPRO (Cheng et al., ) and DISEMBL (Linding et al., ); searching for unstructured protein fragments using DISOPRED (Jones and Cozzetto, ), DISEMBL (Linding et al., ) and DISPRO (Cheng et al., ); the identification of transmembrane helices using TMHMM [http://www.cbs.dtu.dk/services/TMHMM-2.0/ (accessed 30.04.2015)], TOPRED (von Heijne, ), HMMTOP (Tusnády and Simon, ) […]


Tick receptor for outer surface protein A from Ixodes ricinus — the first intrinsically disordered protein involved in vector microbe recognition

Sci Rep
PMCID: 4844993
PMID: 27112540
DOI: 10.1038/srep25205

[…] essed using the MetaDisorder program, which is accessible via the GeneSilico MetaDisorder website. This program combines the results from 13 disorder prediction tools: DisEMBL (version 3), DISOPRED2, DISpro, Globplot, iPDA, IUPred (versions 2), Pdisorder, Poodle-s, Poodle-l, PrDOS, Spritz (versions 2), and RONN. Additionally, three disorder prediction tools offered by the DisProt website were appl […]


Disorder prediction based construct optimization improves activity and catalytic efficiency of Bacillus naganoensis pullulanase

Sci Rep
PMCID: 4835747
PMID: 27091115
DOI: 10.1038/srep24574

[…] he amino acid sequence of the PUL was analyzed using the Disorder Prediction Meta-Server (DisMeta). DisMeta analyzes a protein sequence using eight disorder prediction algorithms (DISEMBL, DISOPRED2, DISpro, FoldIndex, GlobPlot2, IUPred, RONN and VSL2). From each algorithm, disorder predictions are provided separately by the server, along with a plot showing the disorder levels of all amino acid r […]


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DISpro institution(s)
School of Information and Computer Science, Institute for Genomics and Bioinformatics, University of California Irvine, CA, USA
DISpro funding source(s)
Supported by the Institute for Genomics and Bioinformatics at UCI and a Laurel Wilkening Faculty Innovation award, an NIH Biomedical Informatics Training grant (LM-07443-01), an NSF MRI grant (EIA-0321390), a Sun Microsystems award, a grant from the University of California Systemwide Biotechnology Research and Education Program (UC BREP).

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