Provides an aggregated view of all human coding disease-related mutations and SNPs for each protein domain. To build DMDM, all human proteins were aligned to a database of conserved protein domains using a Hidden Markov Model-based sequence alignment tool (HMMer). The resulting protein-domain alignments were used to provide a domain location for all available human disease mutations and polymorphisms. The number of disease mutations and polymorphisms in each domain position are displayed alongside other relevant functional information (e.g. the binding and catalytic activity of the site and the conservation of that domain location). DMDM's protein domain view highlights molecular relationships among mutations from different diseases that might not be clearly observed with traditional gene-centric visualization tools. This domain-centric database provides an ideal framework for studying biological processes relevant to human health, as well as for the integration of other molecular events, such as protein translational modifications and alternative splicing events affecting protein domains.