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|Interface||Command line interface, Graphical user interface|
|Restrictions to use||None|
|Operating system||Unix/Linux, Windows|
No version available
- person_outline DMLE+ Team
- person_outline Bruce Brannala
Publication for DMLE+
Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands
[…] indicating identity by descent (). The length of the shared haplotype varied widely (0.4–5.9 Mb; ), indicating remote shared ancestry. The inferred coalescent time for the last shared ancestor, using DMLE+2.3 software, is 50 generations (95% CI: 45 to 63 generations; ).Consistent with this RG causing CHD and not merely being in linkage disequilibrium with the causal variant, the phenotype of p.Met […]
The Slavic NBN Founder Mutation: A Role for Reproductive Fitness?
[…] or population of all Slavic peoples, either before or after its admixture with the Yamnaya. Unfortunately, our data do not allow formal distinction between these two scenarios.It should be noted that DMLE+ does not estimate the time to the most recent common ancestor (MRCA) of extant deletion carriers, but the actual mutational age. Thus, the deletion may have existed in the population at low freq […]
Founder mutation in KCNJ10 in Pakistani patients with EAST syndrome
[…] To estimate the age of this mutation, we used DMLE+ v.2.3 software, a Bayesian linkage disequilibrium gene mapping method that relies on linkage disequilibrium between pathogenic mutations and multiple linked markers in patients and unrelated hea […]
Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis
[…] tandard and analyzed using Softgenetics GeneMaker software (SoftGenetics, LLC. State College, PA). Haplotype analysis and mutation age estimation analysis were performed using PHASE version 2.1.1 and DMLE+ version 2.3 as described in Supplementary Methods. […]
Mitral regurgitation as a phenotypic manifestation of nonphotosensitive trichothiodystrophy due to a splice variant in MPLKIP
[…] m unrelated Pakistani individuals, all of whom do not have TTDN but 48 of whom have partially overlapping phenotypes, i.e. intellectual disability, corneal disease, nail dystrophy, and hair loss. The DMLE+ program was used to estimate the age of the haplotype . For haplotype age estimation, the following parameters were used: autosomal recessive model of inheritance; Pakistani population growth […]
A recurrent F8 mutation (c.6046C>T) causing hemophilia A in 8% of northern Italian patients: evidence for a founder effect
[…] The DMLE+ software requires an estimation of the population growth rate (r) and the proportion of disease‐bearing chromosome (f). The population growth rate (r) was estimated by the following equation, as […]
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