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Fits replicated methylation measurements from the Illumina HM450K BeadChip (or 450K array) spatially across the genome using a Gaussian kernel. DMRcate identifies and ranks the most differentially methylated regions across the genome based on tunable kernel smoothing of the differential methylation (DM) signal. The method is agnostic to both genomic annotation and local change in the direction of the DM signal, removes the bias incurred from irregularly spaced methylation sites, and assigns significance to each DMR called via comparison to a null model. DMRcate provides functionality for filtering probes possibly confounded by SNPs and cross-hybridisation. It includes bedGraph generation, GRanges generation and plotting functions.

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DMRcate classification

DMRcate specifications

Software type:
Restrictions to use:
Operating system:
Unix/Linux, Mac OS, Windows
Computer skills:
Command line interface
Biological technology:
Programming languages:
limma, minfi, DMRcatedata

DMRcate distribution


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DMRcate support



  • Timothy J. Peters <>


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CSIRO Digital Productivity Flagship, Riverside Life Sciences Centre, North Ryde, New South Wales, Australia; Epigenetics Program, Garvan Institute of Medical Research, Sydney, Australia; St Vincent’s Hospital, Darlinghurst, New South Wales, Australia; School of Medicine, University of Notre Dame, Darlinghurst, New South Wales, Australia; St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia; CSIRO Food and Nutrition Flagship, Riverside Life Sciences Centre, Sydney, Australia

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