DN-Fold

A deep learning network method to predict if a given query-template protein pair belongs to the same structural fold. The input used stemmed from the protein sequence and structural features extracted from the protein pair. Specifically, DN-Fold predicts if two proteins are from the same fold, taking as input pairwise protein features such as sequence or family information, sequence alignment, sequence–profile alignment, profile–profile alignment, structural features, and structure-seeded profiles.