Unlock your biological data
Epigenetic mechanisms, including DNA methylation, are responsible for determining and maintaining cell fate, stably differentiating the various tissues in our bodies. Increasing evidence shows that DNA methylation plays a significant role in cancer, from the silencing of tumor suppressors to the activation of oncogenes and the promotion of metastasis. Recent studies also suggest a role for DNA methylation in drug resistance.
(Trimarchi et al., 2011) Cancer epigenetics: a perspective on the role of DNA methylation in acquired endocrine resistance. Chin J Cancer.