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DNA Methylation Entropy Analysis Software DMEAS

Analyzes the distribution of DNA methylation patterns for the quantification of epigenetic heterogeneity. DMEAS supports the analysis of both locus-specific and genome-wide bisulfite sequencing data. It progressively scans the mapping results of bisulfite sequencing reads to extract DNA methylation patterns for contiguous CpG dinucleotides. It determines the DNA methylation level and calculates methylation entropy for genomic segments to enable the quantitative assessment of DNA methylation variations observed in cell populations.

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DMEAS classification

DMEAS specifications

Software type:
Restrictions to use:
Output format:
Tab-delimited text, images
Programming languages:
Command line interface, Graphical user interface
Input format:
Bismark output (.bis)
Operating system:
Computer skills:

DMEAS distribution


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DMEAS support


  • Hehuang Xie <>


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Center in Computation Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; Division of Medical Informatics and Systems, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA

Funding source(s)

This work was supported by grants from the Natural Science Foundation of China [31201002, 81270633].

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