DNA-protein interactions analysis software tools | Epigenomics
DNA methylation is an epigenetic mechanism where a methyl group is added to cytosines placed in CG dinucleotides (CpGs). This process regulates cellular gene expression and is responsible for biological processes such as X chromosome inactivation. Disruption of the methylation pattern can lead to diseases such as cancer (Kulis et al., 2010; Hassler et al., 2012) or diabetes (Maria et al., 2014; Enquobahrie et al., 2015). DNA methylation can be modified by environmental exposures (e.g. smoking (Steenaard et al., 2015; Simpkin et al., 2015; Joubert et al., 2016)) so it is becoming a common tool in epidemiological studies.
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(Steenaard et al., 2015) Tobacco smoking is associated with methylation of genes related to coronary artery disease. Clin Epigenetics.
(Simpkin et al., 2015) Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies. Hum Mol Genet.
(Joubert et al., 2016) DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis. Am J Hum Genet.
(Ruiz-Arenas and González, 2017) Redundancy analysis allows improved detection of methylation changes in large genomic regions. BMC Bioinformatics.