DNA-Protein interactions databases
Chromatin is a genome-organizing platform, regulating gene expression, cell division and differentiation, etc. Epigenetic regulation, such as DNA methylation, histone modifications and variants, plays a key role in controlling chromatin structure. A combination of multiple epigenetic marks exist at the whole genome level, and specific combinations of epigenetic marks are meaningful in biological function (Strahl and Allis, 2000). Epigenomic data sets are a rich resource to identify regulatory elements and functional annotations in coding and non-coding regions (ENCODE Project Consortium, 2012).
(Strahl and Allis, 2000) The language of covalent histone modifications. Nature.
(ENCODE Project Consortium, 2012) An integrated encyclopedia of DNA elements in the human genome. Nature.
(Liu et al., 2018) PCSD: a plant chromatin state database. Nucleic Acids Res.